STAMATIS DIAGNOSTIC INSTRUMENT №01 / LOCUS BRAIN USPTO 19/200,539 — ALLOWED VOL. 01 · ED. 03 · MAY 2026 ACCURACY 94.35 SENSITIVITY 94.69 SPECIFICITY 90.82 COMPUTE −73% STAMATIS DIAGNOSTIC INSTRUMENT №01 / LOCUS BRAIN USPTO 19/200,539 — ALLOWED VOL. 01 · ED. 03 · MAY 2026 ACCURACY 94.35 SENSITIVITY 94.69 SPECIFICITY 90.82 COMPUTE −73%
Vol. I · No. 03
Cornerstone Eagle, LLC
Investigational Use

Locus·brain

A Stamatis Diagnostic Instrument
May 08, 2026
Inference live
Build 0.4.7
Manifesto / Field Note 03

The radiologist does not look at every voxel. She knows where to look. We taught a machine that same restraint — and patented it.

— S. Khan, Co-Inventor

Look everywhere
only where it matters.

Patent
US 19/200,539 · Allowed
Grant pending July 2026

Modality
3D MRI · T1c / T2 / FLAIR

First Indication
High-grade glioma detection

Status
Demo / pre-FDA

Upload
MRI scan.

Submit a 3D brain MRI volume to run the patented three-stage probabilistic masking pipeline. Use synthetic or de-identified data only.

FormatsNII / GZ / NPY / DCM / ZIP
Max size200 MB
ModalityT1c · T2 · FLAIR
StatusInvestigational

A HIPAA acknowledgement is required before each upload.

Drop your scan
or browse files
.nii · .nii.gz · .npy · .dcm · .zip · 200MB max
scan.nii.gz
— · processing
00:00
i.
Probabilistic Mask
Identifying high-yield voxels
Pending
ii.
Multimodal Encode
Joint embedding · imaging + text
Pending
iii.
RL Alignment
Calibrating against expert feedback
Pending
Analysis Results
Awaiting study
Upload a brain MRI scan to begin analysis
Awaiting
Awaiting study
Upload a scan to begin
i.Pipeline
→
ii.Imaging
→
iii.Diagnosis
Study STDY—2026—0508—A T1 + Gd · 128×128×128 Slice — / —
ROI · L · FRONTAL 2.4 × 1.9 cm · σ 0.964 2 cm A P R L
Lesion volume—
Focal slice—
Raw probability—
Inference time—
Validation · Internal Cohort

Model
performance.

Accuracy
94.35%
Diagnostic accuracy across n=1,247 held-out 3D MRI volumes from BraTS and partner institutions.
Sensitivity
94.69%
True-positive rate for high-grade glioma. Calibrated against radiologist consensus on the same cohort.
Specificity
90.82%
True-negative rate. Held-out volumes include healthy controls and benign findings to test discrimination.
Locus·brain

A Stamatis Diagnostic Instrument. Published by Cornerstone Eagle, LLC. Patent-protected probabilistic masking for 3D medical imaging. Demo system intended for institutional review and partnership discussion. Not cleared for clinical use.

USPTO Application
19 / 200 / 539
Allowed · March 2026
Grant pending July 2026

Brain Tumor Detection System
3-Stage Probabilistic Masking Pipeline
© MMXXVI Cornerstone Eagle, LLC Set in Instrument Serif & IBM Plex Mono Ed. 03 / Build 0.4.7 / V01